{"product_id":"human-nuclear-factor-erythroid-2-related-factor-2-nrf2-elisa-kit-96t","title":"Human Nuclear Factor Erythroid 2-related Factor 2, NRF2 ELISA Kit, 96T","description":"\u003cp\u003eTranscription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed: 11035812, PubMed: 19489739, PubMed: 29018201, PubMed: 31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed: 11035812, PubMed: 15601839, PubMed: 29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2\/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed: 19489739, PubMed: 29590092). The NFE2L2\/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1\/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2\/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed: 20452972). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed: 7937919).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592524444021,"sku":"BT-E3244Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-nuclear-factor-erythroid-2-related-factor-2-nrf2-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}