{"product_id":"human-nucleotide-binding-oligomerization-domain-containing-protein-2-nod2-elisa-kit-96t","title":"Human Nucleotide-binding Oligomerization Domain-containing Protein 2, NOD2 ELISA Kit , 96T","description":"\u003cp\u003eInvolved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed: 18511561). Component of an autophagy-mediated antibacterial pathway together with ATG16L1 (PubMed: 20637199). Plays also a role in sensing single-stranded RNA (ssRNA) from viruses. Interacts with mitochondrial antiviral signaling\/MAVS, leading to activation of interferon regulatory factor-3\/IRF3 and expression of type I interferon (PubMed: 19701189).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592675406197,"sku":"BT-E5806Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-nucleotide-binding-oligomerization-domain-containing-protein-2-nod2-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}