{"product_id":"human-ras-association-domain-containing-protein-1-rassf1-elisa-kit-96t","title":"Human Ras Association Domain-containing Protein 1, RASSF1 ELISA Kit, 96T","description":"\u003cp\u003ePotential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3\/MST2 and STK4\/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1\/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592758800757,"sku":"BT-E6930Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-ras-association-domain-containing-protein-1-rassf1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}