{"product_id":"human-reversion-inducing-cysteine-rich-protein-with-kazal-motifs-reck-elisa-kit-96t","title":"Human Reversion-inducing Cysteine-rich Protein with Kazal Motifs, RECK ELISA Kit, 96T","description":"\u003cp\u003eFunctions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed: 28289266, PubMed: 30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed: 30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed: 30026314). Also acts as a serine protease inhibitor: negatively regulates Matrix Metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed: 9789069, PubMed: 18194466). Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP) (PubMed: 9789069).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592575922549,"sku":"BT-E4359hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-reversion-inducing-cysteine-rich-protein-with-kazal-motifs-reck-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}