{"product_id":"human-rho-guanine-nucleotide-exchange-factor-1-arhgef1-elisa-kit-96t","title":"Human Rho Guanine Nucleotide Exchange Factor 1, ARHGEF1 ELISA Kit, 96T","description":"\u003cp\u003eSeems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits (PubMed: 9641915, PubMed: 9641916). Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase (PubMed: 9641915, PubMed: 9641916, PubMed: 8810315, PubMed: 30521495). Activated G alpha 13\/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain (PubMed: 9641916). This GEF activity is inhibited by binding to activated GNA12 (PubMed: 9641916). Mediates angiotensin-2-induced RhoA activation (PubMed: 20098430).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592524214645,"sku":"BT-E3234Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-rho-guanine-nucleotide-exchange-factor-1-arhgef1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}