{"product_id":"human-ruvb-like-1-ruvbl1-elisa-kit-96t","title":"Human Ruvb-like 1, RUVBL1 ELISA Kit, 96T","description":"\u003cp\u003ePossesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity (PubMed: 17157868). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed: 14966270). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed: 14966270). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair (PubMed: 14966270). The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage (PubMed: 14966270). Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z\/H2AZ1 from the nucleosome (PubMed: 24463511). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (PubMed: 16230350, PubMed: 21303910). Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1\/TCF1-CTNNB1 complex (PubMed: 10882073, PubMed: 16014379). Essential for cell proliferation (PubMed: 14506706). May be able to bind plasminogen at cell surface and enhance plasminogen activation (PubMed: 11027681).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592756244853,"sku":"BT-E6799Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-ruvb-like-1-ruvbl1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}