{"product_id":"human-serine-threonine-protein-kinase-4-stk4-elisa-kit-96t","title":"Human Serine, Threonine-protein Kinase 4, STK4 ELISA Kit, 96T","description":"\u003cp\u003eStress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3\/MST2 and STK4\/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1\/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1\/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3\/MST2 and STK4\/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53\/TP53 deacetylation, thereby promoting p53\/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB\/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB\/AKT1 signaling and antagonizing formation of AR-chromatin complexes.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592558719349,"sku":"BT-E4154hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-serine-threonine-protein-kinase-4-stk4-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}