{"product_id":"human-serine-threonine-protein-kinase-plk3-plk3-elisa-kit-96t","title":"Human Serine, Threonine-protein Kinase Plk3, PLK3 ELISA Kit, 96T","description":"\u003cp\u003eSerine\/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53\/TP53, p73\/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1\/S transition checkpoint by phosphorylating CDC25A, p53\/TP53 and p73\/TP73. Phosphorylates p53\/TP53 in response to reactive oxygen species (ROS), thereby promoting p53\/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2\/M transition checkpoint. Phosphorylates the transcription factor p73\/TP73 in response to DNA damage, leading to inhibit p73\/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1\/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592538337653,"sku":"BT-E3749Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-serine-threonine-protein-kinase-plk3-plk3-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}