{"product_id":"human-small-ubiquitin-related-modifier-2-sumo2-elisa-kit-96t","title":"Human Small Ubiquitin-related Modifier 2, SUMO2 ELISA Kit , 96T","description":"\u003cp\u003eUbiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed: 26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed: 18408734, PubMed: 18538659, PubMed: 21965678, PubMed: 9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed: 24105744).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592694870389,"sku":"BT-E6184Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-small-ubiquitin-related-modifier-2-sumo2-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}