{"product_id":"human-suppressors-of-cytokine-signaling-1-socs1-elisa-kit-96t","title":"Human Suppressors of Cytokine Signaling 1, SOCS1 ELISA Kit, 96T","description":"\u003cp\u003eSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK\/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2\/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592516350325,"sku":"BT-E2960Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-suppressors-of-cytokine-signaling-1-socs1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}