{"product_id":"human-suppressors-of-cytokine-signaling-3-socs-3-elisa-kit-96t","title":"Human Suppressors of Cytokine Signaling 3, SOCS-3 ELISA Kit , 96T","description":"\u003cp\u003eSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK\/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST\/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2\/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 15601820).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592473653621,"sku":"BT-E0657Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-suppressors-of-cytokine-signaling-3-socs-3-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}