{"product_id":"human-transcription-factor-a-mitochondrial-tfam-elisa-kit-96t","title":"Human Transcription Factor A, Mitochondrial, TFAM ELISA Kit, 96T","description":"\u003cp\u003eBinds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed: 29445193, PubMed: 32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed: 29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed: 20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed: 22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed: 22037172). Is able to unwind DNA (PubMed: 22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed: 1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed: 22841477, PubMed: 19304746). May play a role in organizing and compacting mitochondrial DNA (PubMed: 22037171).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592722067829,"sku":"BT-E6726Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-transcription-factor-a-mitochondrial-tfam-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}