{"product_id":"human-tubulin-polymerization-promoting-protein-tppp-elisa-kit-96t","title":"Human Tubulin Polymerization-promoting Protein, TPPP ELISA Kit, 96T","description":"\u003cp\u003eRegulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed: 31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed: 31522887). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed: 31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (PubMed: 21995432, PubMed: 21316364). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed: 17105200, PubMed: 17693641, PubMed: 18028908, PubMed: 26289831). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (PubMed: 20308065, PubMed: 23093407). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (PubMed: 23093407). Plays a role in cell proliferation by regulating the G1\/S-phase transition (PubMed: 23355470). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (PubMed: 22328514).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592523690357,"sku":"BT-E3198Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-tubulin-polymerization-promoting-protein-tppp-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}