{"product_id":"human-tyrosine-protein-phosphate-non-receptor-type-22-ptpn22-elisa-kit-96t","title":"Human Tyrosine Protein Phosphate Non-receptor Type 22, PTPN22 ELISA Kit, 96T","description":"\u003cp\u003eActs as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz\/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed: 16461343, PubMed: 18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed: 21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed: 16461343). Dephosphorylates the immune system activator SKAP2 (PubMed: 21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed: 23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed: 23991106). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592532963701,"sku":"BT-E3436Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-tyrosine-protein-phosphate-non-receptor-type-22-ptpn22-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}