{"product_id":"human-ubiquilin-2-ubqln2-elisa-kit-96t","title":"Human Ubiquilin 2, UBQLN2 ELISA Kit, 96T","description":"\u003cp\u003ePlays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed: 10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2\/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed: 24215460, PubMed: 18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed: 19148225, PubMed: 20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed: 18199683).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592506159477,"sku":"BT-E2612Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-ubiquilin-2-ubqln2-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}