{"product_id":"human-ww-domain-containing-transcription-regulator-protein-1-wwtr1-elisa-kit-96t","title":"Human Ww Domain-containing Transcription Regulator Protein 1, WWTR1 ELISA Kit, 96T","description":"\u003cp\u003eTranscriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed: 11118213, PubMed: 18227151). The core of this pathway is composed of a kinase cascade wherein STK3\/MST2 and STK4\/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1\/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1\/TAZ (PubMed: 18227151). WWTR1 enhances PAX8 and NKX2-1\/TTF1-dependent gene activation (PubMed: 19010321). In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed: 18568018). Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex (PubMed: 18568018). Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition (PubMed: 18227151, PubMed: 18568018).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592619635061,"sku":"BT-E4702Hu-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/human-ww-domain-containing-transcription-regulator-protein-1-wwtr1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}