{"product_id":"ku-70-acetyl-lys338-rabbit-polyclonal-antibody-100ul","title":"Ku-70 (Acetyl Lys338) Rabbit Polyclonal Antibody, 100ul","description":"\u003cp\u003edevelopmental stage:Expression does not increase during promyelocyte differentiation.|disease:Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to p70 and p86. Existence of a major autoantigenic epitope or epitopes on the C-terminal 190 amino acids of p70 containing the leucine repeat. The majority of autoantibodies to p70 in most sera from patients with SLE seem to be reactive with this region.|Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The Ku p70\/p86 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The Ku p70\/p86 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression.|induction:In osteoblasts| by FGF2.|PTM:Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-51 does not affect DNA repair.|Belongs to the ku70 family.|Contains 1 Ku domain.|Contains 1 SAP domain.|subunit:Heterodimer of a 70 kDa and a 80 kDa subunit. The dimer associates in a DNA-dependent manner with PRKDC to form the DNA-dependent protein kinase complex DNA-PK| and with the LIG4-XRCC4 complex. The dimer also associates with NARG1| and this complex binds to the osteocalcin promoter and activates osteocalcin expression. In addition| the 70 kDa subunit binds to the osteoblast-specific transcription factors MSX2| RUNX2 and DLX5. Interacts with ELF3. Interactis with XRCC6BP1.|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56509012574581,"sku":"BT-AP10946-100ul","price":247.5,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon4_b9646263-7fda-4fd2-82e8-9047834a0edb.jpg?v=1767148117","url":"https:\/\/www.labcart.com\/products\/ku-70-acetyl-lys338-rabbit-polyclonal-antibody-100ul","provider":"LabCart Life Science","version":"1.0","type":"link"}