{"product_id":"mek-kinase-3-polyclonal-antibody-50ul","title":"MEK Kinase-3 Polyclonal Antibody, 50ul","description":"\u003cp\u003eMAP3K3 product is a 626-amino acid polypeptide that is 96. % identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4. -kb transcript that appears to be ubiquitously expressed. Mitogen-activated protein kinase kinase kinase 3 directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1\/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514073657717,"sku":"BT-AP05335-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_6.jpg?v=1768209536","url":"https:\/\/www.labcart.com\/products\/mek-kinase-3-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}