{"product_id":"mouse-beclin-1-becn1-elisa-kit-96t","title":"Mouse Beclin 1, BECN1 ELISA Kit, 96T","description":"\u003cp\u003ePlays a central role in autophagy (PubMed: 10604474, PubMed: 12372286, PubMed: 19270693, PubMed: 28445460). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed: 19270693, PubMed: 25275521). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed: 25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed: 25275521). May play a role in antiviral host defense (By similarity). Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592778428789,"sku":"BT-E1134Mo-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/mouse-beclin-1-becn1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}