{"product_id":"mouse-cerebellin-1-cbln1-elisa-kit-96t","title":"Mouse Cerebellin-1, CBLN1 ELISA Kit , 96T","description":"\u003cp\u003eRequired for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses (PubMed: 16234806). Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components (PubMed: 20395510). On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2 (PubMed: 21410790). NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles (PubMed: 23141067). Required for CBLN3 export from the endoplasmic reticulum and secretion (PubMed: 17030622, PubMed: 17331201). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (By similarity). Essential for long-term maintenance but not establishment of excitatory synapses (PubMed: 29691328). Inhibits the formation and function of inhibitory GABAergic synapses in cerebellar Purkinje cells (PubMed: 24467251). The cerebellin Peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase\/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592802185589,"sku":"BT-E1928Mo-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/mouse-cerebellin-1-cbln1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}