{"product_id":"mouse-elav-like-protein-1-elavl1-elisa-kit-96t","title":"Mouse Elav-like Protein 1, ELAVL1 ELISA Kit, 96T","description":"\u003cp\u003eRNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (PubMed: 24394384). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3\/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity). With ZNF385A, binds the 3'-UTR of p53\/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53\/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (PubMed: 21402775). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed: 27616329).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592807788917,"sku":"BT-E2047Mo-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/mouse-elav-like-protein-1-elavl1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}