{"product_id":"mouse-high-mobility-group-protein-b2-hmgb2-elisa-kit-96t","title":"Mouse High Mobility Group Protein B2, HMGB2 ELISA Kit, 96T","description":"\u003cp\u003eMultifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and\/or bringing distant regulatory sequences into close proximity (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (PubMed: 9184213). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA\/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (PubMed: 19890330). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER\/RAGE (By similarity). Has antimicrobial activity in gastrointestinal epithelial tissues (By similarity). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (PubMed: 25306442). May play a role in germ cell differentiation (PubMed: 11262228). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (PubMed: 24391977). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt\/beta-catenin pathway (PubMed: 19805379).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592820175221,"sku":"BT-E2133Mo-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/mouse-high-mobility-group-protein-b2-hmgb2-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}