{"product_id":"mouse-histone-deacetylase-6-hdac6-elisa-kit-96t","title":"Mouse Histone Deacetylase 6, HDAC6 ELISA Kit, 96T","description":"\u003cp\u003eResponsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed: 9891014). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed: 9891014). Histone deacetylases act via the formation of large multiprotein complexes (PubMed: 9891014). In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin (PubMed: 19893491). Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy (By similarity). In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome (By similarity). Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy (PubMed: 22819792).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592820339061,"sku":"BT-E2134Mo-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/mouse-histone-deacetylase-6-hdac6-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}