{"product_id":"mouse-integrin-beta-1-itgb1-elisa-kit-96t","title":"Mouse Integrin Beta-1, ITGB1 ELISA Kit, 96T","description":"\u003cp\u003eIntegrins alpha-1\/beta-1, alpha-2\/beta-1, alpha-10\/beta-1 and alpha-11\/beta-1 are receptors for collagen. Integrins alpha-1\/beta-1 and alpha-2\/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2\/beta-1, alpha-3\/beta-1, alpha-4\/beta-1, alpha-5\/beta-1, alpha-8\/beta-1, alpha-10\/beta-1, alpha-11\/beta-1 and alpha-V\/beta-1 are receptors for fibronectin. Alpha-4\/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5\/beta-1 is a receptor for fibrinogen. Integrin alpha-1\/beta-1, alpha-2\/beta-1, alpha-6\/beta-1 and alpha-7\/beta-1 are receptors for lamimin. Integrin alpha-6\/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed: 10634791). Integrin alpha-4\/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9\/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3\/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3\/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3\/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V\/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7\/beta-1 integrin, regulates cell adhesion and laminin matrix deposition (PubMed: 12941630). Involved in promoting endothelial cell motility and angiogenesis (PubMed: 15181153). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules (PubMed: 21768292). May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (PubMed: 18804435). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40\/CD40LG signaling (By similarity). [Isoform 2]: Isoform 2 displaces isoform 1 in striated muscles.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592822403445,"sku":"BT-E2156Mo-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/mouse-integrin-beta-1-itgb1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}