{"product_id":"mouse-lymphocyte-activation-gene-3-protein-lag3-elisa-kit-96t","title":"Mouse Lymphocyte Activation Gene 3 Protein, LAG3 ELISA Kit, 96T","description":"\u003cp\u003eLymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed: 12209638, PubMed: 12421911, PubMed: 12672063, PubMed: 15100286, PubMed: 15634887, PubMed: 30580966). Delivers inhibitory signals upon binding to ligands, such as FGL1 (PubMed: 30580966). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (PubMed: 30580966). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (PubMed: 12209638, PubMed: 12421911, PubMed: 12672063, PubMed: 15100286, PubMed: 15634887). May inhibit antigen-specific T-cell activation in synergy with PDCD1\/PD-1, possibly by acting as a coreceptor for PDCD1\/PD-1 (PubMed: 21300912). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells (PubMed: 12209638, PubMed: 12421911, PubMed: 12672063, PubMed: 15100286, PubMed: 15634887). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (PubMed: 15485628). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (PubMed: 19201841). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed: 12209638, PubMed: 12421911, PubMed: 15634887). [Secreted lymphocyte activation gene 3 protein]: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation\/maturation and driving Th1 immune response.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592830300533,"sku":"BT-E2220Mo-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/mouse-lymphocyte-activation-gene-3-protein-lag3-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}