{"product_id":"npc1-rabbit-polyclonal-antibody-100ul","title":"NPC1 Rabbit Polyclonal Antibody, 100ul","description":"\u003cp\u003eThis gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus| 13 transmembrane domains| and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal\/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease| a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal\/lysosomal compartments.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56512600834421,"sku":"BT-AP11562-100ul","price":247.5,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon4_b9646263-7fda-4fd2-82e8-9047834a0edb.jpg?v=1767148117","url":"https:\/\/www.labcart.com\/products\/npc1-rabbit-polyclonal-antibody-100ul","provider":"LabCart Life Science","version":"1.0","type":"link"}