{"product_id":"plb-polyclonal-antibody-20ul","title":"PLB Polyclonal Antibody, 20ul","description":"\u003cp\u003eThe protein encoded by PLN (phospholamban)is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in PLN are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56508423635317,"sku":"BT-AP07256-20ul","price":97.2,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_3.jpg?v=1766971577","url":"https:\/\/www.labcart.com\/products\/plb-polyclonal-antibody-20ul","provider":"LabCart Life Science","version":"1.0","type":"link"}