{"product_id":"rat-cytochrome-p450-7a1-cyp7a1-elisa-kit-96t","title":"Rat Cytochrome P450 7A1, CYP7A1 ELISA Kit, 96T","description":"\u003cp\u003eA cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed: 1694852, PubMed: 2335522). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed: 1694852, PubMed: 2335522). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (PubMed: 1694852, PubMed: 2335522). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (By similarity).\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56592907796853,"sku":"BT-E0915Ra-96T","price":370.98,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/ELISA_Kit_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/rat-cytochrome-p450-7a1-cyp7a1-elisa-kit-96t","provider":"LabCart Life Science","version":"1.0","type":"link"}