{"product_id":"rbl2phospho-ser952-rabbit-polyclonal-antibody-50ul","title":"RBL2(Phospho Ser952) Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eKey regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and| in particular| that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2| leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation| associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.|miscellaneous:G0-restricted expression.|PTM:During G0 and early G1 phase of the cell cycle| phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.|Belongs to the retinoblastoma protein (RB) family.|subunit:Interacts with AATF. Interacts with SUV420H1 and SUV420H2 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4| E2F5| LIN9| LIN37| LIN52| LIN54| MYBL1| MYBL2| RBL1| RBL2| RBBP4| TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9| LIN37| LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1.|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56515539108213,"sku":"BT-AP12244-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/rbl2phospho-ser952-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}