{"product_id":"rfwd3-polyclonal-antibody-100ul","title":"RFWD3 Polyclonal Antibody, 100ul","description":"\u003cp\u003eRFWD3, also named as RNF201, is a E3 ubiquitin-protein ligase that mediates the ubiquitination of p53\/TP53 in the late response to DNA damage, and acts as a positive regulator of p53\/TP53 stability, thereby regulating the G1\/S DNA damage checkpoint. RFWD3 may act by catalyzing the formation of short polyubiquitin chains on p53\/TP53 that are not targeted to the proteasome. In response to ionizing radiation, It interacts with MDM2 and enhances p53\/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53\/TP53. (PMID: 20173098 ) From BLAST result, this antibody is specific to RFWD3. 45kd and 55kd maybe splicesome of RFWD3.\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56516710269301,"sku":"BT-AP07780-100ul","price":247.5,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon4_b9646263-7fda-4fd2-82e8-9047834a0edb.jpg?v=1767148117","url":"https:\/\/www.labcart.com\/products\/rfwd3-polyclonal-antibody-100ul","provider":"LabCart Life Science","version":"1.0","type":"link"}