{"product_id":"rfx5-rabbit-polyclonal-antibody-50ul","title":"RFX5 Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eA lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency| or the bare lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B| C| and D all lead to a deficiency in RFX| a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al.| 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. \u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56515540975989,"sku":"BT-AP04449-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/rfx5-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}