{"product_id":"sigir-polyclonal-antibody-50ul","title":"SIGIR Polyclonal Antibody, 50ul","description":"\u003cp\u003eActs as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.,Belongs to the interleukin-1 receptor family.,Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,Contains 1 TIR domain.,subunit:Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6.,tissue specificity:Mainly expressed in epithelial tissues such as kidney, lung and gut.,\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56516060447093,"sku":"BT-AP14223-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_5.jpg?v=1767678439","url":"https:\/\/www.labcart.com\/products\/sigir-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}