{"product_id":"stat2-acetyl-lys384-rabbit-polyclonal-antibody-50ul","title":"Stat2 (Acetyl Lys384) Rabbit Polyclonal Antibody, 50ul","description":"\u003cp\u003eSignal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors| Jak kinases (TYK2 and JAK1) are activated| leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize| associate with ISGF3G\/IRF-9 to form a complex termed ISGF3 transcription factor| that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes| which drive the cell in an antiviral state.|PTM:Tyrosine phosphorylated in response to IFN-alpha.|Belongs to the transcription factor STAT family.|Contains 1 SH2 domain.|subcellular location:Translocated into the nucleus upon activation by IFN-alpha\/beta.|subunit:Interacts with ISGF3G\/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha\/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.|\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56515564306805,"sku":"BT-AP12834-50ul","price":162.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_1.jpg?v=1766393459","url":"https:\/\/www.labcart.com\/products\/stat2-acetyl-lys384-rabbit-polyclonal-antibody-50ul","provider":"LabCart Life Science","version":"1.0","type":"link"}