{"product_id":"tab1-monoclonal-antibody-100ul","title":"TAB1 Monoclonal Antibody, 100ul","description":"\u003cp\u003eThe protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7\/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14\/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced tr\u003c\/p\u003e","brand":"BT LAB","offers":[{"title":"Default Title","offer_id":56514675540341,"sku":"BT-MCA1181-100ul","price":270.0,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0843\/2671\/1640\/files\/Antibody_main_Dungeon_6.jpg?v=1768209536","url":"https:\/\/www.labcart.com\/products\/tab1-monoclonal-antibody-100ul","provider":"LabCart Life Science","version":"1.0","type":"link"}