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SKU: E-AB-16129_20μL-ES
ACO1 Polyclonal Antibody, 20 μL
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:0.2 mg/mL
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Calculated Molecular Weight:98kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:98kDa
Dilution:WB 1:1000-1:5000
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Application:WB
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Research Areas:Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism;Signal Transduction
Species Reactivity:Human;Mouse;Rat
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Target Synonym:ACO 1;ACO1;ACOC;Aconitase 1 soluble;Aconitase;Aconitase1;Aconitate hydratase;ACONS;Citrate hydro lyase;Citrate hydro-lyase;Cytoplasmic aconitate hydratase;Ferritin repressor protein;IRE BP 1;IRE-BP 1;IREB 1;IREB1;IREBP;IREBP1;Iron regulatory protein 1;Iron responsive element binding protein 1;Iron-responsive element-binding protein 1;IRP 1;IRP1;OTTHUMP00000045233
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Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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