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SKU: E-AB-F1385E_100T-ES
APC Anti-Human CD192/CCR2 Antibody[K036C2], 100 T
CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4). Two spliced variants were initially described for CCR2 (CCR2A and CCR2B). These variants differ in their terminal carboxyl tails. Monocyte adhesion to the arterial endothelium and subsequent migration into the intima are central events in the pathogenesis of atherosclerosis. CCR2 and MCP-1 have been associated to atherosclerotic plaques. MCP-1 is induced by modified-LDL in endothelial cells and may trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Local overexpression of MCP-1 at vessel walls induces infiltration of macrophages and formation of atherosclerotic lesions. Obesity induces an inflammatory state that is implicated in many clinically important complications, including insulin resistance, diabetes, atherosclerosis, and non-alcoholic fatty liver disease. CCR2 influences the development of obesity and associated adipose tissue inflammation.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shelf Life:12 months
Storage:This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
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Application:FCM
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Research Areas:Cell Adhesion;Cell Biology;Immunology;Innate Immunity;Neuroinflammation;Neuroscience
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Target Synonym:CC-CKR-2;CCR2A;CCR2B;CKR2;CKR2A;CKR2B;CMKBR2;MCP-1-R
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Clonality:Monoclonal
Conjugation:APC
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