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SKU: E-AB-67371_120μL-ES
(KO Validated) CTCF Polyclonal Antibody, 120 μL
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:83kDa
Observed Molecular Weight:140kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:83kDa
Dilution:WB 1:500-1:2000
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Application:WB
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Research Areas:Cancer; Epigenetics and Nuclear Signaling
Species Reactivity:Human; Mouse; Rat
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Target Synonym:Transcriptional repressor CTCFL;Brother of the regulator of imprinted sites;CCCTC-binding factor;CTCF paralog;CTCF-like protein;Cancer/testis antigen 27;CT27;Zinc finger protein CTCF-T;CTCFL;BORIS
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Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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