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SKU: E-AB-90227_120μL-ES
RNF114 Polyclonal Antibody, 120 μL
E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:21kDa/25kDa
Observed Molecular Weight:26KDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:21kDa/25kDa
Dilution:WB 1:500-1:2000
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Application:WB
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Research Areas:Epigenetics and Nuclear Signaling
Species Reactivity:Human; Mouse
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Target Synonym:RNF114;PSORS12;ZNF313
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Buffer:PBS with 0.02% sodium azide,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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