BT LAB

SKU: BT-E6143Hu-96T

Human Serine/Arginine-rich Splicing Factor 1, SFRS1 ELISA Kit , 96T

Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:9.31ng/L

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Application:ELISA

Detection Target:SRSF1

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Detection Range: 20-4500ng/L

Research Areas:Epigenetics and Nuclear Signaling

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Test Principle:Sandwich

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Assay Time:1h 30m

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