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BT LAB
SKU: BT-E1842Ra-96T
Rat Activity-regulated Cytoskeleton-associated Protein, ARC ELISA Kit, 96T
Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (PubMed: 29328916). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation (PubMed: 29328916). ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons (PubMed: 29328916). Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory (PubMed: 10818134, PubMed: 17088211, PubMed: 17088212, PubMed: 17088213). Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis (PubMed: 17088211, PubMed: 17088212). Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses (PubMed: 23791196). Accumulates at weaker synapses, probably to prevent their undesired enhancement (PubMed: 22579289). This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material (PubMed: 29328916). Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (PubMed: 10818134). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity).
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Product Specification
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Brands:BT LAB
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Place of Origin:China
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Sensitivity:0.48ng/L
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Features and Capabilities
Application:ELISA
Detection Target:ARC
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Detection Range: 1-400ng/L
Research Areas:Neuroscience
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Reactivity:Rat
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Test Principle:Sandwich
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Assay Time:1h 30m
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