BT LAB

SKU: BT-E3243Hu-96T

Human Cyclin-dependent Kinase Inhibitor 1, CDKN1A ELISA Kit, 96T

May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed: 11595739). Plays an important role in controlling cell cycle progression and DNA damage-induced G2 arrest (PubMed: 9106657).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:9.94ng/L

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Application:ELISA

Detection Target:CDKN1A

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Detection Range: 20-4500ng/L

Research Areas:Others

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Assay Time:1h 30m

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