BT LAB

SKU: BT-E5197Hu-96T

Human DNA-binding Protein Ikaros, IKZF1 ELISA Kit, 96T

Transcription regulator of hematopoietic cell differentiation (PubMed: 17934067). Binds gamma-satellite DNA (PubMed: 17135265, PubMed: 19141594). Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity). Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed: 17135265, PubMed: 17934067).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:10.06ng/L

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Application:ELISA

Detection Target:IKZF1

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Detection Range: 20-4500ng/L

Research Areas:Others

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