BT LAB

SKU: BT-E3860Hu-96T

Human Vitamin D 25-hydroxylase, CYP2R1 ELISA Kit, 96T

A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol) (PubMed: 12867411, PubMed: 15465040, PubMed: 18511070). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives (PubMed: 15465040, PubMed: 18511070). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed: 12867411, PubMed: 15465040, PubMed: 18511070).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:5.19ng/L

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Application:ELISA

Detection Target:CYP2R1

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Detection Range: 10-2000ng/L

Research Areas:Cardiovascular

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Assay Time:1h 30m

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