BT LAB

SKU: BT-MCA1126-100ul

Shh Monoclonal Antibody, 100ul

This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved| the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a d

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Concentration:1 mg/ml

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Storage:-20°C for 1 year

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Features and Capabilities

Application:WB, ELISA

Detection Target:SHH

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Research Areas:Cancer; Stem cells; Metabolism; Epigenetics and nuclear signaling; Developmental biology

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Reactivity:Human

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Clonality:Monoclonal

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Formulation:Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.

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