BT LAB

SKU: BT-AP06104-50ul

ASK1(Phospho Thr838) Rabbit Polyclonal Antibody, 50ul

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.|cofactor:Magnesium.|enzyme regulation:Contains an N-terminal autoinhibitory domain. Activated by phosphorylation at Thr-838| inhibited by phosphorylation at Ser-966 and Ser-1033. Binds to| and stabilizes MAP3K6 and is activated by MAP3K6 by phosphorylation on Thr-838.|Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6| which in turn activate the JNK and p38 MAP kinases| respectively. Overexpression induces apoptotic cell death.|induction:By TNF-alpha. Inhibited by HIV-1 Nef.|Belongs to the protein kinase superfamily.|Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|Contains 1 protein kinase domain.|subunit:Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L.|tissue specificity:Abundantly expressed in heart and pancreas.|

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Concentration:1 mg/ml

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Storage:-20°C for 1 year

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Application:WB, ELISA

Detection Target:MAP3K5

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Research Areas:Cardiovascular; Cell biology

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Reactivity:Human, Rat, Mouse

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Clonality:Polyclonal

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Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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