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SKU: E-AB-52350_200μL-ES
ALKBH8 Polyclonal Antibody, 200 μL
ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. Three isoforms exist for ALKBH8 due alternative splicing of the gene.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Calculated Molecular Weight:75 kDa
Observed Molecular Weight:Refer to figures
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:75 kDa
Dilution:WB 1:500-1:2000;IHC 1:25-1:100
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Application:WB;IHC
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Research Areas:Cancer;Epigenetics and Nuclear Signaling
Species Reactivity:Human
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Target Synonym:4930562C03Rik;8030431D03Rik;9430088N01Rik;ABH8;alkB alkylation repair homolog 8 (E. coli);alkB alkylation repair homolog 8;AlkB homologue 8;ALKB8;ALKBH8;Alkylated DNA repair protein alkB homolog 8;FLJ38204;MGC10235;OTTHUMP00000211286;OTTHUMP00000211287;Probable alpha-ketoglutarate-dependent dioxygenase ABH8;RGD1304687;S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8;tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
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Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
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Conjugation:Unconjugated
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