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SKU: E-AB-52520_20μL-ES
CBFB Polyclonal Antibody, 20 μL
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Calculated Molecular Weight:22 kDa
Observed Molecular Weight:Refer to figures
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:22 kDa
Dilution:WB 1:500-1:2000;IHC 1:30-1:150
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Application:WB;IHC
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Research Areas:Cancer;Epigenetics and Nuclear Signaling
Species Reactivity:Human;Mouse
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Target Synonym:CBF b;CBF beta;CBF-beta;CBFB;CBFbeta;Core binding factor beta subunit;core binding factor subunit beta;Core-binding factor subunit beta;PEA 2;PEA2;PEA2 beta;PEA2-beta;PEA2beta;PEBB;PEBP 2B;PEBP2 beta;PEBP2-beta;PEBP2B;PEBP2beta;Polyomavirus enhancer binding protein 2 beta subunit;Polyomavirus enhancer-binding protein 2 beta subunit;SL3 3 enhancer factor 1 beta subunit;SL3 3 enhancer factor 1 subunit beta;SL3-3 enhancer factor 1 subunit beta;SL3/AKV core binding factor beta subunit;SL3/AKV core-binding factor beta subunit
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Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
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Conjugation:Unconjugated
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