BT LAB

SKU: BT-AP14958-50ul

Chk2(Phospho Thr387) Polyclonal Antibody, 50ul

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutati

€162,00 EUR
€162,00 EUR
2-4 weeks
Hassle-Free Warranty
Safe & Secure Payment
Livetime Tech Support
  • Specification
  • Downloads
  • Reviews
€162,00
ADD TO CART
ADD TO CART

Product Specification

Basic Information

Brands:BT LAB

Model Number:

Place of Origin:China

Warranty:

Safety Performance:

Protection Class:

Sterile Status:

Reconstitution:

Shipping:

Battery:

Battery Service Life:

Component:

Technical Specifications

Capacity:

Concentration:1 mg/ml

Dimension [D×W×H]:

Diameter:

Length:

Width:

High:

Volume:

Volume Range:

Speed:

Speed Range:

Max.Speed:

Max. RCF:

Temperature Range:

Operating Temperature Range:

Permissible Ambient Temperature :

Permissible Relative Humidity:

Input voltage:

Power Requirements:

Voltage/Frequency:

Sensitivity:

Specificity:

Precision:

Speed Accuracy:

Volume Accuracy:

Particle Size:

Pore Size:

Binding Capacity:

Calculated Molecular Weight:

Observed Molecular Weight:

Purity:

Shelf Life:

Storage:-20°C for 1 year

Random Error:

Acceleration/Braking time:

Aspiration Speed:

Calculated Molecular Weight:

Dilution:

Driving Motor DC motor:

Em:

Ex:

Endotoxin:

Flow rate [liquid]:

Features and Capabilities

Application:WB, IHC-p, IF, ELISA

Detection Target:CHEK2

Detection Type:

Detection Range:

Research Areas:Cancer; Epigenetics and nuclear signaling

Species Reactivity:

Reactivity:Human, Mouse, Rat

Target Synonym:

Test Principle:

Quantitative/Qualitative :

Result Type:

Materials :

Assay Time:

Autoclave component:

Available Rotor Adapters:

Binding Capacity:

Bio-activity:

Bottom Shape:

Bottom Type:

Buffer:

Cap Color:

Clonality:Polyclonal

Conjugation:

Coupled Ligand:

Cover Type:

Detection Instrument :

Dispensing Speed:

Display:

Form:

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Graduation:

Growth Area:

Download File