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SKU: E-AB-30054_200μL-ES
Cleaved-NOTCH1 (V1754) Polyclonal Antibody, 200 μL
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:273kDa
Observed Molecular Weight:110kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:273kDa
Dilution:WB 1:500-2000;IHC 1:50-300;IF 1:50-300
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Application:WB;IHC-p;IF
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Research Areas:Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Developmental Biology;Neuroscience;Stem Cells
Species Reactivity:Human;Mouse;Rat
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Target Synonym:hN1;Neurogenic locus Notch homolog protein 1;NICD;NOTC1;Notch 1;Notch 1 intracellular domain;Notch homolog 1 translocation associated (Drosophila);notch1;TAN1;Translocation-associated notch protein TAN-1
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Buffer:PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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