BT LAB

SKU: BT-AP10412-100ul

Histone H2A.Z (Acetyl Lys12) Rabbit Polyclonal Antibody, 100ul

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin| limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation| DNA repair| DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones| also called histone code| and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.|mass spectrometry:Monoisotopic| not modified PubMed:16457589|PTM:Acetylated on Lys-5| Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.|PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.|PTM:Not phosphorylated.|Belongs to the histone H2A family.|subunit:The nucleosome is a histone octamer containing two molecules each of H2A| H2B| H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.|

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Concentration:1 mg/ml

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Storage:-20°C for 1 year

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Application:WB, ELISA

Detection Target:H2AFZ

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Research Areas:Epigenetics and nuclear signaling

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Reactivity:Human, Mouse, Rat

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Clonality:Polyclonal

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Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

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